Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.020 | GeneticVariation | BEFREE | The aim of this study was to investigate the association of five extensively-studied polymorphisms in PTGS2 (rs689466, rs5275, rs20417) and CYP2E1 (rs2031920, rs6413432) genes with lung cancer risk in a large northeastern Chinese population. | 22761909 | 2012 |
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0.020 | GeneticVariation | BEFREE | RESULTS COX-2 rs20417 polymorphism had a significant association with reduced risk of lung cancer under homozygous and recessive models, and similar results were observed in white and population-based subgroups under 2 and 3 contrasts, respectively. | 26624903 | 2015 |
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0.020 | GeneticVariation | BEFREE | Our meta-analysis demonstrated that COX-2 rs5275 and rs689466 polymorphism significantly decrease the risk of lung cancer in Asians but not in Caucasians, indicating COX-2 could serve as a potential diagnostic marker for lung cancer. | 30170377 | 2018 |
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0.020 | GeneticVariation | BEFREE | Carriers of rs689466-G mutant allele had a 28% (95% CI: 0.57-0.92; P = 0.008) reduced risk of developing lung cancer relative to the AA genotype carriers. | 22761909 | 2012 |
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0.020 | GeneticVariation | BEFREE | The Cox-2 intron 6 (rs2066826) genotypes were distributed differently between the lung cancer and control groups. | 20530427 | 2010 |
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0.020 | GeneticVariation | BEFREE | Additionally, rs2066826 polymorphism manifested a strong correlation with increased risk of lung cancer under 5 genetic models. | 26624903 | 2015 |
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0.020 | GeneticVariation | BEFREE | Our meta-analysis demonstrated that COX-2 rs5275 and rs689466 polymorphism significantly decrease the risk of lung cancer in Asians but not in Caucasians, indicating COX-2 could serve as a potential diagnostic marker for lung cancer. | 30170377 | 2018 |
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0.020 | GeneticVariation | BEFREE | The risk for lung cancer associated with the rs5275-C mutant allele was decreased by 60% (95% CI [confidence interval]: 0.21-0.74; P = 0.004) under the recessive model. | 22761909 | 2012 |
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0.010 | GeneticVariation | BEFREE | IL-10 1082G/A, 819C/T and 592C/A polymorphisms might be risk factors for LC. | 22160576 | 2012 |